Name: D-Mannose
SKU: 3173
Availability: InStock

D-Mannose

£10,000.00

High-purity D-Mannose (≥99%) produced via certified enzymatic conversion, ensuring batch-to-batch consistency for nutraceutical, pharmaceutical, and functional food applications.

Competitive Advantage Spotlight
Zero artificial additives, non-GMO, and third-party tested for endotoxins and residual solvents—delivering supply chain reliability at scale with lead times 30% faster than industry average.

Description

1. Product Overview

D-Mannose is a naturally occurring monosaccharide, structurally related to glucose, produced via certified enzymatic hydrolysis and crystallization processes for high-purity industrial applications. Its primary industrial use is as a precision intermediate in nutraceutical, pharmaceutical, and specialty food formulations targeting urinary tract health, along with applications in glycoprotein synthesis and bioprocessing. The key value proposition is a verified ≥99% purity, endotoxin-controlled profile, and non-GMO source material, enabling predictable performance in sensitive biological environments. Strategically, this product is critical for global manufacturers seeking to scale urinary health solutions and biopharmaceutical excipients amid rising demand for antibiotic-alternative preventive care.

2. Key Specifications & Technical Characteristics

Chemical Composition: D-Mannose (C₆H₁₂O₆), CAS No. 3458-28-4, derived from non-GMO corn or birch via enzymatic conversion
Purity Grade: ≥99.0% (HPLC), with pharmaceutical-grade (EP/USP) and food-grade options
Physical Characteristics:
- Form: Fine, free-flowing crystalline powder
- Color: White to off-white
- Particle size: D90 ≤ 150 µm (standard); customized milling available (D90 50–200 µm)
- Bulk density: 0.55–0.75 g/cm³ (untapped); 0.75–0.95 g/cm³ (tapped)
- Moisture content: ≤1.0% (Karl Fischer)
Impurity Profile: Heavy metals ≤10 ppm, lead ≤0.5 ppm, arsenic ≤1 ppm, residual solvents meet ICH Q3C
Packaging Options: 25 kg multi-layer kraft/PE bags; 500 kg FIBCs; custom sterile pharmaceutical drums (20 kg)
Shelf Life: 36 months from manufacture date when stored in original sealed packaging under cool (15–25°C), dry (≤50% RH) conditions

3. Core Industrial Applications

Nutraceutical Manufacturing: Primary use in tablet, capsule, powder stick, and gummy formulations for urinary tract infection (UTI) prevention. D-Mannose outperforms cranberry extracts due to clinically validated mechanism of binding E. coli FimH adhesins, with no caloric interference or sugar metabolism issues in diabetic populations.
Pharmaceutical Intermediates: Used as a starting material for synthesis of mannose-6-phosphate (M6P) in enzyme replacement therapies (ERT) for lysosomal storage disorders. Its high purity reduces downstream purification steps by ≥30%, lowering cost of goods.
Bioprocessing & Cell Culture: Serves as a controlled osmolyte and glycosylation modulator in mammalian cell culture media (CHO cells). Superior to D-glucose for maintaining glycoprotein yield consistency, with batch-to-batch variability <2% RSD.
Specialty Food & Infant Formula: Added as a prebiotic-like sugar and excipient in medical foods. Its low glycemic index (GI = 0) and resistance to fermentation provide functional advantage over fructose or maltodextrin in enteral nutrition products.

4. Competitive Advantages

Quality Consistency: ISO 9001:2015 and FSSC 22000 certified facilities. Each lot tested for purity, residual solvents, heavy metals, microbial limits (TAMC ≤100 cfu/g), and endotoxins (<10 EU/g for pharma grade). CoA provided with every shipment.
Supply Reliability: Dual sourcing from North America and Europe with 6-month rolling forecast commitment. Dedicated buffer stock of 60+ MT maintained in climate-controlled warehouses on three continents.
Logistics Capability: Expedited 5-day dispatch for standard grades; 15-day lead time for custom particle size/pharma-grade documentation. Real-time trackable shipping via partnered freight forwarders (Kuehne+Nagel, DSV).
Price Competitiveness: Volume pricing 15–25% below European spot averages through vertically integrated enzymatic production, eliminating costly botanical extraction steps.
Sustainability: 98% solvent recovery rate in crystallization; birch-derived variant uses renewable forestry with FSC-certified sourcing. Non-GMO project verified and Kosher/Halal certified available.
Technical Support: Access to application lab for dissolution studies, compatibility testing, and regulatory dossier support (DMF Type II available upon NDA).

5. Commercial & Supply Information

Minimum Order Quantity (MOQ): 500 kg for standard grade (25 kg bags); 1,000 kg for pharmaceutical/USP grade
BULK 20MT Loading Capacity: 20 metric tons net weight fits as:
- 20′ dry container: 800 × 25 kg bags (20 MT) with palletized configuration (20 Euro pallets)
- 20′ container max payload: 21.5 MT; our standard loading is 20 MT to allow sampling access
Incoterms Offered: EXW (warehouse – Rotterdam / Chicago / Shanghai), FOB, CIF, DDP upon qualification
Lead Time for 20MT Bulk Order: 12–18 working days after advance payment or LC confirmation
Payment Terms: Letter of Credit (L/C at sight), T/T advance (30/70), or net 30 days for established credit-approved buyers

Additional information

Benefits of D-Mannose:	Urinary Tract Health: D-Mannose is primarily used to prevent and treat urinary tract infections (UTIs), particularly those caused by E. coli bacteria. It works by preventing the bacteria from adhering to the walls of the urinary tract, thus reducing infection risk. Bladder Health: D-Mannose may help manage chronic bladder conditions, like interstitial cystitis (IC), by reducing irritation and discomfort associated with bladder inflammation. Antibacterial Properties: It has mild antibacterial properties, particularly against E. coli, the bacterium responsible for most UTIs. Support for Kidney Health: By helping with urinary tract infections, D-Mannose indirectly supports kidney health by preventing infections that can spread to the kidneys. Gut Health: D-Mannose is a sugar, but unlike glucose, it is absorbed in small amounts in the gut, which is why it’s generally safe for individuals with insulin resistance or those managing blood sugar.
Ingredients (Typical Formulation for Supplements): Active Ingredient:	D-Mannose (the primary active ingredient) Inactive Ingredients (Varies by brand): Capsule Ingredients (for capsules/tablets): Gelatin, magnesium stearate, rice flour, silicon dioxide, or other binders depending on the form of the supplement. Powdered Form: May include citric acid, stevia, or other flavorings. Preservatives/Stabilizers: Often minimal, depending on the product type.
Nutritional Information (per serving—varies by product):	Since D-Mannose is typically sold as a dietary supplement, the nutritional content varies depending on the brand, but here’s a general idea of what you might find: Calories: 4-5 kcal per 1-gram serving (varies by product) Carbohydrates: 1-2 grams (most of it coming from D-Mannose itself) Sugar: 1 gram (almost entirely D-Mannose) Protein/Fat: 0 grams Fiber: 0 grams (as D-Mannose is a simple sugar)
Prescription Status:	Over-the-Counter: D-Mannose is available as a dietary supplement and does not require a prescription in most places. It can be found in capsule, powder, and tablet forms. Not a Prescription Medication: It is not considered a prescription medication, but it may be recommended by a healthcare provider, especially for people prone to UTIs.
Precautions:	Possible Side Effects: D-Mannose is generally well-tolerated, but excessive intake could lead to mild gastrointestinal discomfort, like bloating or diarrhea. Interaction with Medications: There are no major known interactions, but it’s always a good idea to consult a healthcare provider before starting a new supplement, especially if you have preexisting conditions or are taking medications.
Summary:	D-Mannose is widely used for urinary tract health, especially for preventing UTIs. It's available over-the-counter as a supplement and typically contains minimal additional ingredients beyond the active sugar itself. It’s considered safe for most people but should be used with care if you have underlying health concerns. Always follow recommended dosage and check with a healthcare provider if uncertain.

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