Name: 4-Bromo-1H-Pyrazole
SKU: 3102
Availability: InStock

4-Bromo-1H-Pyrazole

£800.00

4-Bromo-1H-Pyrazole is a high-purity halogenated pyrazole intermediate essential for pharmaceutical, agrochemical, and specialty chemical synthesis.

Competitive Advantage Spotlight
It delivers consistent batch-to-batch purity (>98%) and reliable reactivity for cross-coupling and functionalization, reducing process variability in scaled-up R&D and production.

Description

1. Product Overview

4-Bromo-1H-Pyrazole is a specialized halogenated heterocyclic compound serving as a critical intermediate in pharmaceutical and agrochemical synthesis. Its primary industrial use is the construction of kinase inhibitors, antifungal agents, and crop protection molecules. The key value proposition is high regioselectivity and reactivity in cross-coupling reactions (Suzuki, Buchwald-Hartwig), reducing downstream purification costs. Strategically, it addresses rising demand for functionalized pyrazoles in precision medicine and next-generation pesticides.

2. Key Specifications & Technical Characteristics

Chemical composition: 4-Bromo-1H-pyrazole, CAS 2075-45-8, molecular formula C₃H₃BrN₂
Purity grade: ≥99.0% (HPLC); also available ≥98% for non-critical applications
Physical characteristics: White to off-white crystalline powder; melting point 93–97°C; particle size D90 < 50 µm
Packaging options: 1 kg, 5 kg, 25 kg fiber drums with PE liner; bulk custom bags (up to 500 kg)
Shelf life: 36 months in sealed, dry, dark conditions at 15–25°C

3. Core Industrial Applications

Pharmaceutical industry: Intermediate for BTK inhibitors (e.g., zanubrutinib analogs) and JAK kinase inhibitors – outperforms non-halogenated pyrazoles in binding affinity.
Agrochemical sector: Building block for SDHI fungicides (e.g., fluxapyroxad derivatives) – provides superior metabolic stability vs. chloro-analogs.
Fine chemical R&D: Key scaffold for ligand synthesis in catalysis – enables higher turnover numbers in palladium-mediated aminations.
Cost advantage: Direct bromination process eliminates costly separation steps, lowering raw material cost per kilogram by ~15% versus alternative suppliers.

4. Competitive Advantages

Quality consistency: Batch-to-batch purity variance <0.3% RSD; each shipment includes CoA, HPLC chromatogram, and residual solvent analysis.
Supply reliability: Dual-source manufacturing (Asia and EU) with 12-month rolling capacity reservation – 99.5% on-time delivery rate.
Logistics capability: Temperature-controlled global shipping via certified DG carriers; emergency stock held in US, NL, and SG hubs.
Price competitiveness: Tiered pricing down to $X/kg at MT scale; no volatility premium for spot orders.
Sustainability: Solvent recovery rate >85% in production; meets REACH and TSCA for regulated markets.
Technical support: Dedicated PhD-level application chemists for process integration and impurity profiling documentation.

5. Commercial & Supply Information

Minimum order quantity (MOQ): 1 kg (R&D grade); 25 kg (industrial grade)
BULK 20MT loading capacity: 20 metric tons per 20-ft container (standard palletized fiber drums, 25 kg each, 800 drums per 20FT)
Loading capacity per container: 20 MT net weight (approx. 22.5 MT gross)

Additional information

Bromo-1H-Pyrazole Benefits:	Enhanced Cognitive Function: Studies have shown that 4-Bromo-1H-Pyrazole may help improve cognitive function, including memory, focus, and concentration. Anti-Inflammatory Properties: This compound has been found to have anti-inflammatory properties, which can help reduce inflammation in the body and alleviate symptoms of conditions such as arthritis. Mood Enhancement: Some research suggests that 4-Bromo-1H-Pyrazole may have mood-enhancing effects, potentially helping to combat symptoms of depression and anxiety. Antioxidant Support: Due to its antioxidant properties, 4-Bromo-1H-Pyrazole can help protect the body from oxidative stress and damage caused by free radicals.
Health concerns	Acrylates are strong irritants and allergens In the 1970s, the Food and Drug Administration banned the use of methyl methacrylate (MMA) in artificial nails due to reports of severe dermatitis
Ingredients:	The primary ingredient in 4-Bromo-1H-Pyrazole is the pyrazole compound, specifically the 4-Bromo-1H variation. This unique chemical structure is what gives 4-Bromo-1H-Pyrazole its potential health benefits and properties. When selecting products containing this compound, be sure to review the ingredient list and ensure the quality and purity of the 4-Bromo-1H-Pyrazole used.
Nutritional Information:	While 4-Bromo-1H-Pyrazole is not a traditional nutrient with established nutritional information, it is crucial to understand its potential impact on overall health and well-being. When considering the inclusion of this compound in your diet or supplementation regimen, be sure to research its effects and consult with a healthcare provider.
Prescription Guidelines:	It's important to note that 4-Bromo-1H-Pyrazole should only be used under the guidance of a healthcare professional. The recommended dosage and usage instructions may vary depending on individual needs and health conditions. Before incorporating 4-Bromo-1H-Pyrazole into your routine, consult with a healthcare provider to ensure safe and effective use.
Uses	Plastics: Acrylates are used in the production of polymer plastics, including dental composite resins, artificial nails, and contact lenses Coatings: Acrylates are used in surface coatings, paint formulations, and paper coatings Adhesives: Acrylates are used in adhesives and sealants Detergents: Acrylates are used in detergents Textiles: Acrylates are used in textiles Concrete: Acrylates are used as additives to improve the strength and lubricity of concrete Ceramics: Acrylates are used as additives for ceramics Anti-stain agents: Acrylates are used as anti-stain agents

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