Tosyl Chloride

Description

1. Product Overview

Tosyl Chloride is a high-purity sulfonyl chloride reagent essential for tosylation reactions in organic synthesis, pharmaceutical intermediate production, and polymer chemistry. Its primary industrial use lies in protecting amines and alcohols, as well as manufacturing sulfonate esters and sulfonamides. The key value proposition is exceptional reactivity consistency and low impurity profiles, enabling higher yields and reduced purification steps. Strategically, it is a critical enabler for global API (active pharmaceutical ingredient) supply chains and specialty chemical manufacturing, where reaction predictability directly impacts time-to-market and production economics.

2. Key Specifications & Technical Characteristics

• Chemical composition: p-Toluenesulfonyl chloride (C₇H₇ClO₂S), CAS 98-59-9

• Purity grade: ≥99.0% (GC assay) / Pharmaceutical intermediate grade

• Key impurities controlled: Free acid ≤0.3%, p-Toluenesulfonic acid ≤0.5%, Chlorinated byproducts ≤0.1%

• Physical form: White to off-white crystalline powder

• Melting point: 65–69°C (strict range ensures batch-to-batch uniformity)

• Density: ~1.33 g/cm³ at 25°C

• Particle size: 90% through 20 mesh (standardized for rapid dissolution)

• Packaging options: 25 kg fiber drums with PE liner, 200 kg net HDPE drums, custom IBC totes (1,000 kg)

• Shelf life: 24 months from date of manufacture when stored below 30°C in dry, sealed conditions

3. Core Industrial Applications

• Pharmaceutical manufacturing: Tosylation of alcohols and phenols in API synthesis (e.g., production of dronedarone, certain β-lactam intermediates). Outperforms crude-grade alternatives by minimizing hydrolyzed acid content, which can degrade acid-sensitive substrates.

• Agrochemicals: Synthesis of sulfonamide-based herbicides and fungicides. Superior purity reduces downstream neutralization costs and waste volume by 15–20% compared to standard technical grades.

• Dye & pigment industry: Intermediate for optical brighteners and reactive dyes. Consistent particle size ensures uniform reactivity in batch reactors, eliminating yield variability.

• Polymer additives: Production of heat stabilizers and plasticizers. Low free-acid content prevents premature catalyst poisoning in polymerization systems.

• Specialty chemicals: Blocking agent for peptide synthesis and precursor for sulfonylureas. The ≥99.0% purity enables one-pot processes without intermediate chromatography.

4. Competitive Advantages

• Quality consistency: Statistical process control (SPC) across every batch; lot-to-lot variability ≤0.2% purity. Full certificate of analysis (COA) with each shipment, including residual solvent and heavy metal profiles.

• Supply reliability: Multi-site production (Asia and Europe) with 5,000 MT annual capacity. Safety stock equivalent to 60 days of forecasted demand.

• Logistics capability: Temperature-controlled storage during transit; global distribution hubs in Rotterdam, Houston, and Shanghai enable 5–7 day lead time to major industrial zones.

• Price competitiveness: Tiered pricing for contract volumes (≥100 MT/year) benchmarked against monthly ICIS pricing. No price premium for >99.0% grade vs. standard 98.5% from non-integrated suppliers.

• Sustainability & documentation: IBC return/reuse program reduces packaging waste by 40%. Available REACH, TSCA, and K-REACH compliance dossiers. SDS provided in 12 languages.

• Technical support: Dedicated process development team assists with tosylation optimization, scale-up troubleshooting, and impurity profiling.

5. Commercial & Supply Information

• Minimum order quantity (MOQ): 20 MT (single product line / one specification)

• Bulk loading capacity (20MT order): 20 MT ±5% per 20-ft standard container (18 pallets of 25 kg drums = 18 MT; or 100 × 200 kg drums = 20 MT exactly)

• Container configuration for 20 MT: 20-ft general-purpose dry container, 80 drums of 250 kg net each (palletized, 4 drums per pallet, 20 pallets) – or 200 kg drums as customer preference. Maximum net weight 20,160 kg per container.

• Lead time for MOQ: 14 days from confirmed purchase order and LC/advance payment