2-Acetylthiophene

Description

1. Product Overview

2-Acetylthiophene is a high-purity heterocyclic intermediate, widely utilized in the synthesis of advanced pharmaceuticals, agrochemicals, and specialty polymers. Its primary industrial use lies as a key building block for thiophene-derived active pharmaceutical ingredients (APIs), particularly in anti-inflammatory and cardiovascular compounds. The key value proposition is its exceptional reactivity consistency and low impurity profile, which reduces downstream purification costs and improves final product yield. Strategically, with increasing demand for thiophene-based molecules in drug discovery and conductive materials, secure supply of premium-grade 2-Acetylthiophene is critical for maintaining competitive manufacturing timelines.

2. Key Specifications & Technical Characteristics

• Chemical composition: 2-Acetylthiophene (C₆H₆OS), ≥99.0% purity (GC area %)

• Purity grade: Pharmaceutical / Industrial intermediate grade (residual solvents controlled)

• Physical characteristics:

  • Form: Pale yellow to colorless liquid (solidifies at low temperature, melting point 10–11°C)

  • Color (APHA): ≤100

  • Density (25°C): 1.138–1.142 g/cm³

  • Refractive index (n²⁰/D): 1.564–1.567

  • Water content (KFT): ≤0.2%

  • Assay (by GC): 99.0–101.0% on anhydrous basis

• Packaging options:

  • 25 kg HDPE drums with PTFE-lined caps

  • 200 kg UN-certified steel drums (hazardous goods class 3)

  • IBC totes (1,000 kg) for bulk contract buyers

• Shelf life: 24 months from manufacture date when stored under nitrogen in original sealed containers at 2–8°C (cool, dry, dark conditions)

3. Core Industrial Applications

• Pharmaceutical synthesis: Key intermediate for tiaprofenic acid (NSAID), antiplatelet agents, and atypical antipsychotics – outperforms substituted thiophenes due to higher electrophilicity of the acetyl group, reducing reaction steps by up to 20%.

• Agrochemicals: Precursor for thiophene-based fungicides and herbicides – provides superior metabolic stability in soil compared to benzene analogs, lowering field reapplication rates.

• Advanced materials: Monomer for conductive polythiophene derivatives in organic electronics – yields narrower bandgap polymers versus unsubstituted thiophene, improving charge mobility.

• Flavor & fragrance: Minor use as a savory flavor precursor (roasted/meaty notes) – offers heat stability above 200°C, unlike many ketones that degrade during extrusion.

Cost advantage example: In API manufacturing, 99.0% grade reduces recrystallization cycles from three to one versus 97–98% competitive grades, saving $12–15 per kg of final drug substance.

4. Competitive Advantages

• Quality consistency: Lot-to-lot variability <0.3% relative standard deviation (RSD) for assay; each batch includes GC-FID chromatogram and residual solvent analysis (ICH Q3C compliant).

• Supply reliability: Dual-sourced synthesis routes (thiophene acetylation and Friedel-Crafts variants) ensure no single raw-material bottleneck; safety stock maintained at 150% of average monthly demand.

• Logistics capability: Dedicated hazardous cargo lanes (UN 1993) with temperature-controlled container options (15–25°C) available for all maritime and air freight routes.

• Price competitiveness: Tiered pricing based on annual volume (20MT+ contracts) reduces per-kg cost by 18–22% compared to spot purchases from specialty chemical distributors.

• Sustainability: Manufacturing process reduces volatile organic compound (VOC) emissions by 40% versus traditional AlCl₃-catalyzed methods via heterogeneous acid catalyst recovery system.

• Technical support: Full regulatory package including TDS, MSDS (revised GHS), COA, and method validation reports (HPLC/GC) provided digitally within 24 hours of order confirmation.

5. Commercial & Supply Information

• Minimum Order Quantity (MOQ): 1 MT (metric ton) for initial trial order; 5 MT for contract pricing

• Bulk 20 MT Loading Capacity: 20 MT net weight per 20-ft standard container (100 x 200 kg drums, palletized, 4 drums per pallet, 25 pallets total)

• Container fill factor: 20 MT / 20’ dry container (max payload 21.5 MT, allowing margin for packaging)

• Lead time: 15–20 days from order confirmation for bulk orders; spot orders (1–5 MT) shipped within 7–10 days ex-warehouse (Rotterdam, Houston, or Shanghai hub)