4-Bromo-2-Chlorobenzaldehyde

Description

1. Product Overview

4-Bromo-2-Chlorobenzaldehyde is a high-purity, functionalized aromatic aldehyde serving as a critical intermediate in pharmaceutical, agrochemical, and advanced material synthesis. Its primary industrial application lies in constructing complex molecular architectures, particularly for active pharmaceutical ingredients (APIs) and high-performance liquid crystal compounds. The key value proposition is exceptional regio-selectivity and reactivity, enabling downstream manufacturers to achieve higher yields and reduce purification steps. Strategically, as global supply chains for halogenated benzaldehydes tighten, securing a reliable source of this specific substitution pattern is essential for mitigating synthesis bottlenecks and maintaining production continuity.

2. Key Specifications & Technical Characteristics

• Chemical composition: 4-Bromo-2-chlorobenzaldehyde (C₇H₄BrClO); molecular weight 219.46 g/mol

• Purity level: ≥ 99.0% (HPLC, area %);杂质 profile individually controlled (each impurity ≤ 0.2%)

• Physical characteristics:

  • Form: Crystalline powder

  • Color: White to off-white

  • Melting point: 58–62°C

  • Loss on drying: ≤ 0.5%

• Packaging options:

  • 25 kg fiber drums with double PE liners

  • 100 kg HDPE drums

  • Custom 5 kg lab sampling packs

• Shelf life: 24 months from manufacture date when stored in tightly sealed, original container under dry, ambient conditions (15–30°C)

3. Core Industrial Applications

• Pharmaceutical manufacturing: Key intermediate for synthesis of selective kinase inhibitors and GPCR-targeted APIs. Outperforms non-halogenated or singly halogenated benzaldehydes due to dual halogen electronic effects, enabling faster reaction kinetics and higher regiocontrol in Suzuki-Miyaura cross-couplings.

• Agrochemicals: Used in novel fungicide and herbicide molecular backbones. The bromine and chlorine substituents provide metabolic stability, improving field persistence compared to unsubstituted analogs.

• Liquid crystal & OLED materials: Building block for polar liquid crystal dopants. Superior purity minimizes charge trapping in electronic devices, directly improving switching speeds and operational lifetime.

• Cost advantage: Higher reactivity allows lower catalyst loadings (e.g., Pd reductions of 30–40%) vs. alternative halogenated aldehydes, reducing overall process costs.

4. Competitive Advantages

• Quality consistency: Batch-to-batch purity variance < 0.3%; full HPLC chromatogram and residual solvent analysis (GC) provided with each shipment. Meets ICH Q7 guidelines.

• Supply reliability: Dedicated multipurpose reactor line with 12 MT/month baseline capacity; buffer stock held in regional hubs (Asia, EU, North America). Force majeure contingency plan documented.

• Logistics capability: DG-classified as environmentally hazardous (UN 3077, Packing Group III). Certified hazmat team ensures compliance with IMDG / IATA / ADR. Typical dispatch within 5 business days of payment.

• Price competitiveness: Direct manufacturer pricing with no distributor markup; volume tier discounts starting at 1 MT. Transparent cost structure tied to bromine and chlorobenzaldehyde feedstock indices.

• Technical support: Process R&D team available for custom impurity profiling, method validation, and stability study design. Certificate of Analysis (CoA) and MSDS included.

5. Commercial & Supply Information

• Minimum Order Quantity (MOQ): 25 kg (one fiber drum) for initial qualification; 1 MT for regular production supply

• Bulk 20MT Loading capacity: 18 MT per 20-foot container (palletized, 720 × 25 kg drums)

• Lead time: 15–20 days for MOQ; 30 days for full container load after deposit

• Payment terms: Letter of Credit (L/C at sight) or T/T advance for new accounts; net 30 days after qualification for contract customers