Tert-Butyl Carbamate

Description

1. Product Overview
Tert-Butyl Carbamate (CAS 4248-19-5) is a high-purity amine protecting agent essential for peptide synthesis and pharmaceutical intermediate manufacturing. Its primary industrial use lies in the selective introduction of the Boc (tert-butoxycarbonyl) protecting group for amino functions, enabling complex multi-step organic synthesis. The key value proposition is exceptional stability under basic conditions and clean, rapid removal under mild acidic conditions—directly improving API synthesis yields and reducing purification overhead. Strategically, with the global peptide therapeutics market exceeding $40 billion, reliable Boc-protecting reagents like Tert-Butyl Carbamate are critical enablers of supply chain resilience for contract development and manufacturing organizations (CDMOs) and large-scale pharma.

2. Key Specifications & Technical Characteristics

• Chemical composition: Tert-Butyl Carbamate (C₅H₁₁NO₂); Molecular weight: 117.15 g/mol

• Purity level: ≥ 99.0% (GC) / Pharmaceutical intermediate grade

• Physical characteristics: White to off-white crystalline powder; Melting point: 105–110°C; Bulk density: ~0.65 g/cm³; Particle size: 100% through 40 mesh

• Packaging options: 25 kg fiber drums with inner PE liner; 500 kg supersacks; custom IBC totes for multi-ton orders

• Shelf life: 24 months from manufacture when stored in original sealed container at 2–8°C, protected from moisture and light

3. Core Industrial Applications

• Primary industries: Pharmaceutical manufacturing (APIs, peptide therapeutics, small-molecule oncology drugs); Fine chemical synthesis; Biotechnology R&D; Agrochemical intermediates

• Specific use cases: Boc protection of amino acids in solid-phase peptide synthesis (SPPS); Intermediate for synthesis of protease inhibitors (e.g., HIV, HCV); Building block for tertiary butyl-based carbamates in CNS drug candidates

• Performance advantage over alternatives: Unlike benzyl carbamates (Cbz) or Fmoc, Boc group removal requires only mild acid (TFA or HCl in dioxane) — no hydrogenation or strong base — reducing side reactions and enabling scalable manufacturing. Yields typically 10–15% higher than generic-grade carbamates due to minimal di-tert-butyl dicarbonate residual.

• Cost advantage: Higher reaction efficiency reduces total cost per kg of final API by lowering purification steps and solvent usage — verified through 12-month industrial trial data.

4. Competitive Advantages

• Quality consistency: Batch-to-batch variability < 0.5% relative standard deviation (RSD); ISO 9001:2025 certified manufacturing with full HPLC and GC-MS traceability.

• Supply reliability: Dedicated capacity of 800 MT/year across two redundant production lines; 48-hour shipment commitment for stock-keeping units (SKUs) from regional hubs (USA, NL, CN, IN).

• Logistics capability: UN3077 compliant; dangerous goods handling certification; ambient temperature container options with desiccant-controlled packaging to extend shelf life during transit.

• Price competitiveness: Tiered pricing reduces cost per kg by up to 22% for 20 MT+ orders compared to European and North American specialty chemical distributors.

• Sustainability: Solvent recovery rate > 85% in manufacturing; no heavy metal catalysts used; full REACH and TSCA compliance with available EHS data sheets.

• Technical support: Free certificate of analysis (CoA) per batch; stability study reports upon request; application note for Boc-deprotection scale-up provided to qualified buyers.

5. Commercial & Supply Information

• Minimum order quantity (MOQ): 100 kg (trail order) / 5 MT (contract pricing)

• BULK 20MT loading capacity: Standard 20FT container: 16 MT (net) using 25 kg drums palletized; 20 MT (net) using supersacks with optimized stacking

• Lead time: 7–14 days for MOQ; 21 days for 20 MT bulk (ex-works)

• Incoterms supported: EXW, FOB, CIF, DDP (volume-dependent)