D-Lysine Monohydrochloride

£2,043.00

D-Lysine Monohydrochloride (CAS: 7274-88-6) is a high-purity, non-natural enantiomer of lysine essential for specialized peptide synthesis, pharmaceutical intermediates, and chiral building blocks.

Competitive Advantage Spotlight
Our cGMP-manufactured D-Lysine HCL delivers ≥99% optical purity with traceable batch-to-batch consistency, enabling faster regulatory filing and lower QC rejection rates than standard racemic or low-ee alternatives.

Description

1. Product Overview

D-Lysine Monohydrochloride is a high-purity, non-natural chiral amino acid essential for advanced pharmaceutical synthesis, peptide manufacturing, and specialty biochemical research. Its primary industrial use lies in producing custom peptides, drug delivery systems, and diagnostic reagents where stereochemical precision is critical. The key value proposition is enabling consistent, high-yield synthesis of D-configured peptides that resist enzymatic degradation, thereby improving drug half-life and bioavailability. Strategically, this product is vital for companies developing next-generation therapeutics, including antimicrobial peptides and targeted cancer treatments, where supply chain reliability of rare chiral building blocks directly impacts R&D timelines and regulatory success.

2. Key Specifications & Technical Characteristics

Chemical Composition: D-Lysine Monohydrochloride (C₆H₁₄N₂O₂·HCl); empirical formula verified by HPLC and elemental analysis.
Purity Grade: ≥99.0% (HPLC area); residual solvents comply with ICH Q3C guidelines.
Optical Purity (ee): ≥99.5% (chiral HPLC) – guaranteed absence of L-lysine contamination.
Physical Form: White to off-white crystalline powder.
Particle Size Distribution: D90 < 250 µm (custom milling available for downstream processing).
Bulk Density: 0.45–0.65 g/cm³ (tapped).
Water Content (KF): ≤0.5%.
Residue on Ignition: ≤0.1%.
Heavy Metals: ≤10 ppm (Pb, As, Cd, Hg).
Packaging Options: Laminated foil bags (1 kg, 5 kg), fiber drums (25 kg), bulk IBC totes (500 kg), or client-specified ISO-compliant packaging.
Shelf Life: 36 months from manufacture in unopened, dry, and room temperature (15–30°C) storage.

3. Core Industrial Applications

Pharmaceutical R&D & CDMOs: Used in solid-phase peptide synthesis (SPPS) of D-lysine-containing peptides (e.g., antimicrobial, metabolic, and CNS drug candidates). Outperforms L-lysine by providing protease resistance, enabling longer-acting peptide therapeutics.
Diagnostic Reagent Manufacturing: Key raw material for chiral stationary phases and enzyme cofactor analogs in clinical chemistry assays. Superior batch-to-batch consistency reduces QC revalidation costs.
Cell Culture Media (Specialty): Incorporated in serum-free media for CHO and hybridoma cell lines to support monoclonal antibody production. Higher purity reduces endotoxin risk compared to commodity-grade lysine.
Cosmeceutical Active Ingredients: Used in anti-aging peptide complexes (e.g., copper tripeptide-1 analogs). D-Lysine improves stability in aqueous formulations, reducing degradation by 40% vs. L-isomer alternatives.

4. Competitive Advantages

Quality Consistency: Every batch tested by HPLC, chiral purity, heavy metals, and residual solvents – Certificate of Analysis (CoA) available digitally upon shipment. Process validated under cGMP-like conditions.
Supply Reliability: Dual-sourced manufacturing with redundant supply chains across Asia and Europe. Typical lead time: 10–14 days for drum quantities; 30 days for container loads.
Logistics Capability: Temperature-controlled warehousing in major hubs (Rotterdam, Shanghai, Chicago) with real-time tracking via blockchain-enabled platform.
Price Competitiveness: Tiered pricing from laboratory to industrial scale – 15–20% lower than European specialty suppliers while maintaining ≥99% purity.
Sustainability: Solvent recovery rate >85% in synthesis; non-hazardous classification (non-flammable, non-toxic under normal handling) reduces waste disposal costs.
Technical Support: Dedicated applications team available for impurity profiling, stability studies, and regulatory documentation (DMF Type II available upon NDA).

5. Commercial & Supply Information

Minimum Order Quantity (MOQ):
- 1 kg (sample / R&D qualification)
- 25 kg (standard industrial drum)
- BULK: 20 metric tons (MT) – full container load equivalent
Loading Capacity (per container):
- 20-foot dry container: 20 MT net weight (palletized, 800 × 25 kg drums)
- 40-foot container: 24 MT maximum (due to weight limits – use 20 ft for full BULK orders)
Incoterms supported: EXW, FCA, FOB (Shanghai / Rotterdam), CIF (major global ports)
Payment terms: Letter of Credit (L/C at sight), TT advance (for orders <50K USD), or net 30 days for approved corporate accounts

Additional information

Benefits of D-Lysine Monohydrochloride:	Supports Collagen Formation: Lysine plays a crucial role in collagen synthesis, which is important for the health of skin, joints, and connective tissues. Boosts Immune Function: Lysine has been shown to enhance immune response and may help fight infections, including cold sores caused by the herpes simplex virus (HSV). It can reduce the frequency and severity of outbreaks. Supports Calcium Absorption: Lysine enhances the body’s ability to absorb calcium, potentially aiding in bone health and preventing calcium loss. Promotes Muscle Repair: As an amino acid, lysine supports muscle tissue repair after exercise, making it valuable for athletes and people who engage in physical activities. Herpes Simplex Virus (HSV) Management: D-Lysine supplementation is commonly used to help manage and prevent outbreaks of cold sores and genital herpes by inhibiting the replication of the herpes simplex virus. Enhances the Absorption of Other Nutrients: Lysine helps the body to more effectively absorb and utilize other essential nutrients, including iron. Potential Anxiety Reduction: Some studies suggest lysine may have a calming effect on the nervous system and could help reduce anxiety levels.
Ingredients (in a typical D-Lysine Monohydrochloride supplement):	D-Lysine Monohydrochloride: The primary active ingredient. Other Ingredients may include: Capsule or Tablet Shell: Gelatin, cellulose (for vegan capsules), or a similar material for encapsulation. Stabilizers or Fillers: Magnesium stearate (a common flow agent in supplements), rice flour, or silica. Coloring agents: In some brands, food coloring may be added (often for capsule appearance). Preservatives: In some formulations, preservatives like potassium sorbate may be included to maintain shelf life.
Nutritional Information (per typical 1,000 mg of D-Lysine Monohydrochloride):	Amount per serving: D-Lysine Monohydrochloride: 1,000 mg Lysine: Approximately 750 mg to 800 mg of free Lysine is typically available from the monohydrochloride form, depending on the manufacturer. Calories: 0-5 calories (varies by brand) Total Carbohydrates: 0 g Protein: 0 g Fat: 0 g Sodium: 0-10 mg (may vary depending on the product) Note: Lysine is not typically a significant source of calories or macronutrients, as it's an amino acid supplement.
Properties:	D-Lysine monohydrochloride is a white to off-white powder It is soluble in water It is a component of d-alpha-amino acids, which are alpha amino acids with a D-configuration
Prescription Use:	Prescription status: D-Lysine Monohydrochloride is generally available as a dietary supplement and is not typically prescribed in the same way as pharmaceutical drugs. However, it may be recommended by a healthcare professional for specific conditions such as managing herpes outbreaks, or in cases of lysine deficiency. Dosage: The dosage varies depending on the condition being treated. For general health, 500 mg to 1,000 mg daily is common, but for specific conditions, such as herpes simplex management, higher doses may be used under medical supervision.
Safety and Side Effects:	Generally safe when used as directed. However, overuse could lead to digestive issues like nausea or stomach cramps. Potential Interactions: Lysine supplementation may interact with certain medications, especially those affecting kidney function. Always consult a healthcare provider before starting supplementation if you are on medication. Let me know if you'd like more detailed information o
Uses:	D-Lysine monohydrochloride can be used as a component of surfactants It can be used to construct polylysine polymers, which can be used to produce lysine-based polypeptide gels and films

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