Mandelic Acid

£7.80

Mandelic acid is an aromatic alpha hydroxy acid with the molecular formula C6H5CH(OH)CO2H. It is a white crystalline solid that is soluble in water and polar organic solvents. It is a useful precursor to various drugs. The molecule is chiral. The racemic mixture is known as paramandelic acid.

Melting point: 119 °C
3D model (JSmol): Interactive image
Acidity (pKa): 3.41
Appearance: White crystalline powder
ATC code: B05CA06 (WHO) J01XX06 (WHO)

Description

Mandelic Acid: The Gentle Giant of Exfoliation for Radiant Skin

In the ever-evolving world of skincare, new ingredients and formulations are constantly emerging, each promising a path to clearer, brighter, and healthier skin. Among these, mandelic acid has steadily gained popularity for its unique benefits and gentler approach to exfoliation. But what exactly is mandelic acid, and why is it becoming a staple in so many skincare routines?

What is Mandelic Acid?

Mandelic acid is an alpha hydroxy acid (AHA) derived from bitter almonds. Like other AHAs like glycolic and lactic acid, it works by loosening the bonds between dead skin cells on the surface of the skin, promoting cell turnover and revealing a smoother, more radiant complexion.

Why is Mandelic Acid Different?

While the core function of exfoliating remains the same, mandelic acid stands out due to its larger molecular size. This larger size means it penetrates the skin more slowly and evenly, resulting in a gentler exfoliating action. This is particularly beneficial for those with sensitive skin, rosacea, or darker skin tones who may find other AHAs too harsh.

The Benefits of Mandelic Acid:

  • Gentle Exfoliation: As mentioned, the larger molecule provides a more superficial and less irritating exfoliation, making it suitable for sensitive skin.
  • Acne Treatment: Mandelic acid possesses antibacterial properties, which can help combat acne-causing bacteria. It also helps unclog pores, preventing future breakouts.
  • Reduces Hyperpigmentation: By promoting cell turnover, mandelic acid can lighten dark spots, sunspots, and post-inflammatory hyperpigmentation (PIH) caused by acne.
  • Improves Skin Texture: Regular use can smooth rough skin, reduce the appearance of fine lines and wrinkles, and improve overall skin texture.
  • Boosts Collagen Production: Mandelic acid has been shown to stimulate collagen production, which can lead to firmer, more youthful-looking skin.

Who Should Use Mandelic Acid?

Mandelic acid is a versatile ingredient that can benefit a wide range of skin types, but it’s particularly well-suited for:

  • Sensitive skin: Its gentle nature makes it a great option for those who react poorly to other AHAs.
  • Acne-prone skin: Its antibacterial and exfoliating properties can help control breakouts.
  • Those with hyperpigmentation: It can help fade dark spots and even out skin tone.
  • Individuals concerned with aging: Its collagen-boosting ability can help reduce the appearance of fine lines and wrinkles.

How to Incorporate Mandelic Acid into Your Routine:

Mandelic acid is available in various skincare products, including cleansers, serums, toners, and peels. Here’s a general guide:

  • Start Slow: Begin with a lower concentration (around 5-10%) and use it only a few times per week to assess your skin’s tolerance.
  • Apply at Night: AHAs can make your skin more sensitive to the sun, so it’s best to use mandelic acid products in your nighttime routine.
  • Always Wear Sunscreen: Regardless of the time of day, daily sunscreen is crucial when using any AHA to protect your skin from sun damage.
  • Follow Product Instructions: Always read and follow the specific instructions provided with the product you choose.

Potential Side Effects:

While generally well-tolerated, mandelic acid can cause mild side effects in some individuals, such as:

  • Redness: A slight flush or redness may occur, especially upon initial use.
  • Dryness: Exfoliation can sometimes lead to dryness, so ensure you’re using a good moisturizer.
  • Peeling: Mild peeling is normal as the dead skin cells are shed.

If you experience persistent irritation, stop using the product and consult with a dermatologist.

Final Thoughts:

Mandelic acid offers a gentle yet effective approach to exfoliation, making it a valuable addition to many skincare routines. Its ability to address a variety of skin concerns, from acne to hyperpigmentation to signs of aging, makes it a versatile ingredient worth considering. Remember to start slow, listen to your skin, and always protect your skin with sunscreen. With consistent use, mandelic acid can help you achieve a smoother, brighter, and more radiant complexion.

Additional information

Benefits

Exfoliation: Mandelic acid can help with exfoliation, hydration, and firmness.
Acne: Mandelic acid has been studied for its use with acne.
Sensitive skin: Mandelic acid is sometimes considered a gentle AHA, so it may be suitable for people with sensitive skin.

How Does it Work

Mandelic Acid 40% Topical Liquid is a specially crafted formulation that is applied directly to the skin to exert its therapeutic effects. Mandelic acid, an alpha hydroxy acid (AHA) derived from bitter almonds, works primarily by accelerating cell turnover. When applied to the skin, it gently exfoliates the uppermost layer of the epidermis, removing dead skin cells and promoting the emergence of new, healthy skin cells. This process of exfoliation can help to unclog pores, reduce the appearance of fine lines, and improve skin texture and tone.

The mechanism of action of mandelic acid involves breaking the bonds that hold dead skin cells together on the skin's surface. This action not only facilitates exfoliation but also enhances the skin's absorption of other skincare products. By promoting the shedding of the outer skin layer, mandelic acid can also help to fade hyperpigmentation, such as age spots, melasma, and scars, leading to a more even skin tone. Its larger molecular size compared to other AHAs allows for a slower, more even penetration, which can reduce the risk of irritation, making it suitable for sensitive skin types and those new to acid exfoliation.

Additionally, mandelic acid possesses antibacterial properties, making it effective in treating acne-prone skin. It can help to reduce inflammation and bacterial growth associated with acne, and its exfoliating action helps to prevent the formation of new comedones (blackheads and whiteheads). Furthermore, mandelic acid has been found to have some benefit in treating photoaging due to its ability to stimulate collagen production, thereby improving skin elasticity and reducing the appearance of wrinkles.

For patients with rosacea or other inflammatory skin conditions, mandelic acid can provide benefits due to its anti-inflammatory properties. It can help to soothe the skin and reduce redness without causing the irritation that can sometimes result from the use of other AHAs. The formulation's 40% concentration allows for potent therapeutic action, yet it should be used with caution, and sun protection is advised due to the increased sensitivity to UV radiation that can result from exfoliating treatments.

It is important for both patients and prescribers to understand that while mandelic acid can provide significant benefits for various skin conditions, it should be used as part of a comprehensive skin care regimen. It is also essential to introduce mandelic acid gradually into a skincare routine to allow the skin to adapt and to minimize potential irritation. As with any topical treatment, individual responses can vary, and it may take several weeks to observe noticeable improvements in skin condition.

If you have any questions about the Mandelic Acid 40% Topical Liquid formulation or its suitability for a particular skin condition, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this product.

Drug Interactions

Mandelic Acid 40% Topical Liquid is a formulation intended for direct application to the skin. Mandelic acid is an alpha hydroxy acid (AHA) that is commonly used for its exfoliating properties, which can help in the treatment of various skin conditions such as acne, melasma, age spots, and wrinkles. It accelerates cell turnover by dissolving the tiny bonds that hold skin cells together, helping to remove dead skin on the surface that can lead to dull complexions and fine lines.

When using Mandelic Acid 40% Topical Liquid, it is important to consider potential drug interactions, particularly with other topical agents. Concurrent use of other exfoliants, such as other AHAs (glycolic, lactic acid), beta hydroxy acids (salicylic acid), or retinoids (tretinoin, adapalene) can increase the risk of skin irritation, redness, and peeling. It is generally recommended to avoid using multiple exfoliating agents together unless directed by a healthcare provider.

Additionally, products containing benzoyl peroxide should be used with caution, as they may cause a temporary staining of the skin when used with mandelic acid. Sun sensitivity may be increased when using mandelic acid, so it is crucial to apply sunscreen and limit sun exposure while using this product and for a week afterwards. This is because AHAs can make the skin more susceptible to UV damage due to their exfoliating action on the skin's surface.

Patients should also be aware that the use of mandelic acid with topical anesthetics or corticosteroids could potentially increase the absorption of these agents, leading to increased systemic exposure and potential side effects. It is advisable to consult with a healthcare provider before combining such treatments.

It is important to note that while mandelic acid is used topically and is not known to have significant interactions with oral medications, patients should always inform their healthcare provider of all the medications and products they are using, including over-the-counter drugs, herbal supplements, and cosmeceuticals. This will help to ensure safe and effective use of the Mandelic Acid 40% Topical Liquid.

For any questions or concerns regarding the use of Mandelic Acid 40% Topical Liquid or potential drug interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this formulation for both patients and prescribers.

How to use

After cleansing and hydrating, apply a thin layer of mandelic acid to affected areas.
Follow with serums and moisturizer.
Apply SPF as the last step in your morning skincare routine.

Key ingredients

Mandelic Acid, Sodium Hyaluronate Crosspolymer, Tasmannia Lanceolata Fruit/Leaf Extract

Other uses

Mandelic acid is also a useful precursor to various drugs.
It has antibacterial properties.
It's a human xenobiotic metabolite.

Precautions

Do a patch test before using.
Discontinue use if irritation occurs.
Avoid contact with eyes.
If irritation persists, discontinue use and consult a physician.

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